Cool World (1992) on Netflix

When ex-con cartoonist Jack Deebs was behind bars he found escape by creating "Cool World," a cartoon series featuring a voluptuous vixen named Holli Would. But the 'toonsmith becomes a prisoner of his own fantasies when Holli pulls jack into Cool World with a scheme to seduce him and bring herself to life. A hard-boiled detective--the only other human in Cool World--cautions Jack with the law: 'Noids don't have sex with cartoon doodles. The flesh proves weaker than ink, however, as Holli takes human form in Las Vegas, staring in a trans-universal chase that threatens the destruction of both worlds. With a splashy mix of animation and live-action sequences, "Cool World" delivers the hottest action around.